Isomangiferin is an orally active xanthone C-glucoside, and its chemical structure is similar to Mangiferin ( HY-N0290 ). Isomangiferin is an effective VEGFR-2 kinase inhibitor, which can induces cell apoptosis , inhibit the growth, metastasis and angiogenesis of breast cancer . Isomangiferin exerts anti-inflammatory effects by inhibiting the HMGB1/NLRP3/NF-κB signaling pathway, thereby improving the renal function indicators of diabetic mice. Isomangiferin exhibits inhibitory effects on various bacteria and herpes simplex virus type 1 ( HSV-1 ). Isomangiferin promotes the migration and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and reduces cell apoptosis and the production of ROS by activating the AMPK/ACC pathway, thereby facilitating fracture healing.
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