Deoxyandrographolide

CAS No.：79233-15-1
Grade：99.80%
Formula：C20H30O4
M.W.：334.45
Solvent：≥ 2.5 mg/mL (7.47 mM); Clear solution

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Overview

Deoxyandrographolide is an orally active lactone found in the Andrographis paniculata Nees. Deoxyandrographolide shows a K D of 38.4 μM of HDAC1 . Deoxyandrographolide enhances GLUT4 plasma membrane translocation, activates PI3K and AMPK -dependent signaling pathways, suppresses fasting blood glucose, serum insulin , triglycerides, and LDL-cholesterol levels. Deoxyandrographolide enhances HDAC1 expression via inhibited ubiquitination degradation, represses H3K4me3 , improves chromosome stability, and restrains aging biomarkers p16 , p21 , γH2A.X , p53 and ROS production. Deoxyandrographolide interacts with Foot-and-Mouth Disease Virus 3Cpro active site, inhibits protease and IFN -antagonist activity, derepresses ISG expression, and inhibits viral replication. Deoxyandrographolide can be used for the researches of type 2 diabetes mellitus , vascular senescence and virus infection .

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Signaling Pathways > GLUT | Products > Signaling Pathways > HDAC | Products > Signaling Pathways > Virus Protease | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > AMPK | Products > Signaling Pathways > Akt | Products > Signaling Pathways > Histone Demethylase | Products > Signaling Pathways > MDM-2/p53 | Products > Signaling Pathways > IFNAR | Products > Signaling Pathways > Reactive Oxygen Species (ROS)

Product Information

Catalog No.: HY-N0857
CAS No.: 79233-15-1
Molecular Formula: C20H30O4
Molecular Weight: 334.45
Purity: 99.80%
Storage: -20°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solubility: ≥ 2.5 mg/mL (7.47 mM); Clear solution
Availability: In-stock

Source

Original product source

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