Licoflavanone (3′-Prenylnaringenin) is a flavanone with antioxidant, anti-inflammatory and anticancer activities. Licoflavanone can be isolated from the leaf extract of Glycyrrhiza glabra . Licoflavanone downregulates the mTOR/PI3K/AKT signaling pathway to inhibit the proliferation, migration and invasion of cancer cells, while activates Bax , Bad and multiple caspase enzymes to induce apoptosis . Its anti-inflammatory effect is manifested by reducing the nuclear translocation of NF-κB , decreasing the phosphorylation levels of p38, JNK and ERK1/2 , thereby inhibiting the expression of nitric oxide, proinflammatory cytokines, COX-2 and iNOS . Licoflavanone is used in studies on nasopharyngeal carcinoma and related mechanisms.
Products | Products > Disease Areas > Others | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Others | Products > Signaling Pathways > mTOR | Products > Signaling Pathways > Akt | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > JNK | Products > Signaling Pathways > ERK | Products > Signaling Pathways > COX | Products > Signaling Pathways > NO Synthase | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Bacterial
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