(+)-Totarol is a diterpenoid membrane-disrupting agent and membrane structure regulator found in plants of the genus Podocarpus spp . (+)-Totarol inserts into phospholipid model membranes, disrupts phospholipid packing, and impairs the functional integrity of membranes. (+)-Totarol exhibits antibacterial activity against a variety of bacterial species and β-lactam-resistant strains, and its action is associated with changes in membrane physical properties. (+)-Totarol can be used in studies related to bacterial infections.
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