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| Ciproxifan Basic information |
| Product Name: | Ciproxifan | | Synonyms: | CS-757;Ciproxifan (FUB-359);Cyclopropyl[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone;FUB 359;Methanone, cyclopropyl[4-[3-(1H-iMidazol-4-yl)propoxy]phenyl]-;Ciproxifan, >=99%;Methanone, cyclopropyl[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]-;Ciproxifan USP/EP/BP | | CAS: | 184025-18-1 | | MF: | C16H18N2O2 | | MW: | 270.33 | | EINECS: | | Product Categories: | Inhibitors | | Mol File: | 184025-18-1.mol |
| Ciproxifan Chemical Properties |
| Boiling point | 526.9±35.0 °C(Predicted) | | density | 1.231 | | storage temp. | 2-8°C | | solubility | H2O: insoluble | | form | solid | | pka | 14.54±0.10(Predicted) | | color | white |
| Ciproxifan Usage And Synthesis |
| Biological Activity | ciproxifan is a novel and potent antagonist of histamine h3-receptor with a ic50 value of 9.2±1.8nm [1].ciproxifan has shown the in-vitro antagonistic action to h3-receptor with a ic50 value of 9.2±1.8nm. in addition, ciproxifan has been reported to competitively antagonize the (r) α-meha induced relaxation of electrically stimulated guinea pig ileum longitudinal muscle. besides, ciproxifan has been revealed to have the effect on [125i]iodoproxyfan binding with a ki value of 0.7±0.2 nm. apart from these, ciproxifan has been found to be a selective antagonist with pki values of 9.3, 4.9, 4.6, 5.5, 5.4, 4.9, <5.0, 4.8, <5.5 and <5.7 for h3, h2, h1, muscarinic m3, adrenergic α1d, β1, serotonin 5-ht1b, 5-ht2a, 5-ht3 and 5-ht4, respectively [1]. | | references | [1] ligneau x1, lin j, vanni-mercier g, jouvet m, muir jl, ganellin cr, stark h, elz s, schunack w, schwartz j. neurochemical and behavioral effects of ciproxifan, a potent histamine h3-receptor antagonist. j pharmacol exp ther. 1998 nov; 287(2):658-66. |
| Ciproxifan Preparation Products And Raw materials |
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