Other grades of this product :
| OSI-420 Basic information |
| Product Name: | OSI-420 | | Synonyms: | Ethanol, 2-[[4-[(3-ethynylphenyl)aMino]-7-(2-Methoxyethoxy)-6-quinazolinyl]oxy]-, hydrochloride;OSI-420 (DesMethyl Erlotinib,CP-473420);CP-473420;DesMethyl Erlotinib;OSI-420 hydrochloride;OSI-420 (DesMethyl Erlotinib);Erlotinib O-DesMethyl Metabolite IsoMer (M14) HCl;6-O-Desmethyl Erlotinib 2 | | CAS: | 183320-51-6 | | MF: | C21H22ClN3O4 | | MW: | 415.87 | | EINECS: | 200-258-5 | | Product Categories: | Inhibitors | | Mol File: | 183320-51-6.mol |
| OSI-420 Chemical Properties |
| OSI-420 Usage And Synthesis |
| Uses | OSI-420 (Desmethyl Erlotinib,CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells.
| | Uses | OSI 420 can be used in biological study of effects of cytochrome P 450 3A on pharmacokinetic interaction between erlotinib and docetaxel in rats. |
| OSI-420 Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye