Asterriquinone (ARQ), a Asterriquinone analog, is a Grb-2 binding inhibitor. Asterriquinone inhibits the Grb-2 binding activity to tyrosine phosphorylated EGFR , with an IC 50 of 8.37 μM. Asterriquinone is a HIV1 reverse transcriptase inhibitor with a K i of 2.3 μM. Asterriquinone also inhibits Grb-7 and PLC-γ binding activities..
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