Hexacyclinol has moderate anti-Gram-positive bacteria activity, 4-40 μg/mL can inhibit the production of oxidants by polymorphonuclear neutrophils (PMNL) stimulated by zymosan. Hexacyclinol inhibits the growth of L-930 and K 562 cells with IC 50 s of 1.4 μg/mL and 0.4 μg/mL, respectively, and the IC 50 of HeLa cells is 10 μg/mL. Hexacyclinol also has an anti-Plasmodium effect, and its IC 50 for Plasmodium falciparum is 2.4 μg/mL.
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