Other grades of this product :
| Product Name: | AG 825 | | Synonyms: | TYRPHOSTIN AG 825;TYRPHOSTIN C15;AG 825;5-[(BENZTHIAZOL-2-YL)THIOMETHYL]-4-HYDROXY-3-METHOXYBENZYLIDENECYANOACETAMIDE;5-[(BENZOTHIAZOL-2-YL)THIOMETHYL]-4-HYDROXY-3-METHOXYBENZYL-IDENECYANOACETAMIDE;4-HYDROXY-3-METHOXY-5-(BENZOTHIAZOLYLTHIOMETHYL)BENZYLIDENECYANOACETAMIDE;3-[3-[(2-Benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano-
2-Propenamide;Tyrphostin C15, 5-[(Benzothiazol-2-yl)thiomethyl]-4-hydroxy-3-methoxybenzylidenecyanoacetamide | | CAS: | 149092-50-2 | | MF: | C19H15N3O3S2 | | MW: | 397.47 | | EINECS: | | Product Categories: | Protein Kinase | | Mol File: | 149092-50-2.mol |
| AG 825 Chemical Properties |
| storage temp. | −20°C | | solubility | DMSO: soluble | | form | Yellow solid | | Sensitive | Light Sensitive |
| AG 825 Usage And Synthesis |
| Uses | A selective ErbB2 inhibitor | | Uses | AG 825 is a selective ErbB2 (Neu) inhibitor and apoptosis inducer. | | Definition | ChEBI: An organic sulfide that consists of 1,3-benzothiazole-2-thiol in which the hydrogen attached to the sulfur atom is replaced by a 5-[(1E)-3-amino-2-cyano-3-oxoprop-1-en-1-yl]-2-hydroxy-3-methoxybenzyl group. It acts as an epidermal growth
factor receptor antagonist. | | Biological Activity | Selective ErbB2 inhibitor (IC 50 values are 0.15 and 19 mM at ErbB2 and ErbB1 respectively). Preferentially triggers p38 MAP kinase-dependent apoptosis in androgen-independent prostate cancer cells. |
| AG 825 Preparation Products And Raw materials |
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