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| PPACK, DIHYDROCHLORIDE Basic information |
| Product Name: | PPACK, DIHYDROCHLORIDE | | Synonyms: | PPACK, DIHYDROCHLORIDE;PPACK TRIFLUOROACETATE;H-D-PHE-PRO-ARG-CHLOROMETHYLKETONE 2HCL;H-D-PHE-PRO-ARG-CHLOROMETHYLKETONE TFA;H-D-PHE-PRO-ARG-CMK 2HCL;PPACK, DiHCl;PPACK DIHYDROCHLORIDE[D-PHE-PRO-ARG-CHLOROMETHYLKETONE, HCL];D-Phe-Pro-Arg-CMK.HCl | | CAS: | 142036-63-3 | | MF: | C21H32Cl2N6O3 | | MW: | 487.43 | | EINECS: | | Product Categories: | ProteaseInhibitors | | Mol File: | 142036-63-3.mol |
| PPACK, DIHYDROCHLORIDE Chemical Properties |
| storage temp. | 0-6°C | | solubility | ≥49.5 mg/mL in DMSO; ≥32.5 mg/mL in EtOH; ≥37.9 mg/mL in H2O |
| PPACK, DIHYDROCHLORIDE Usage And Synthesis |
| Biological Activity | ppack dihydrochloride is the dihydrochloride form of its active component ppack (d-phenylalanyl-l-prolyl-l-arginine chloromethyl ketone), a potent, selective and irreversible inhibitor of thrombin that inhibits human α-thrombin with inhibition constant kivalue of 0.24 nm. ppack covalently binds to the specific active-site ser of thrombin and cross links with his57 at the binding site forming a tetrahedral ppack-thrombin complex. the complex further binds to and saturates the high-affinity functional thrombin receptors eventually leading to the inhibition of thrombin activation. ppack is currently being investigated as an anti-coagulant to prevent blood coagulation. study results show that ppack is able to dose-dependently inhibit thrombin-induced platelet accumulation.jun t. liu, william paul, michael emerson, carla cicala and clive p. page. thrombin inhibitors and anti-coagulants on thrombin-induced embolization in rabbit cranial vasculature. european journal of pharmacology 264 (1994) 183-190ildiko m. kovach, paul kelley, carol eddy, frank jordan and ahmet baykal. proton bridging in the interactions of thrombin with small inhibitors. biochemistry. 2009; 48(30): 7296-7304martha e. lyon, james s. fine, paul j. henderson and andrew w. lyon. d-phenylalanyl-l-prolyl-l-arginine chloromethyl ketone (ppack): alternative anticoagulant to heparin salts for blood gas and electrolyte specimens. clin. chem. 41/7, 1038-1041 (1995) |
| PPACK, DIHYDROCHLORIDE Preparation Products And Raw materials |
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