Psammaplin A is a marine metabolite. Psammaplin A is a selective HDAC1 ( IC 50 : 45 nM), DNA methyltransferases ( IC 50 : 18.6 nM) and aminopeptidase N (APN) ( IC 50 : 18 μM) inhibitor. Psammaplin A also inhibits DNA topoisomerase and farnesyl protein transferase . Psammaplin A is a PPARγ activator and induces apoptosis . Psammaplin A has antitumor and anti-inflammatory activities. Psammaplin A has antibacterial activity against Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Psammaplin A inhibits angiogenesis.
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