Periplogenin (Standard) is the analytical standard of Periplogenin ( HY-N2414 ). Periplogenin is an orally active cardiac glycoside found in Cortex periplocae . Periplogenin can induce ROS production and necroptosis and cause G0/G1 phase arrest. Periplogenin can inhibit pyroptosis by regulating the NLRP3/Caspase-1/GSDMD signaling. Periplogenin suppresses growth of prostate carcinoma cells by docking to an ATP1A1 protein pocket and forming a hydrogen bond with T804. Periplogenin can be used for the researches of cancer , inflammation and immunology, such as prostate carcinoma, rheumatoid arthritis and psoriasis.
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