Trimyristin is an orally active compound. Trimyristin can be isolated from the seeds of nutmeg ( Myristica fragrans ). Trimyristin inhibits the activities of acetylcholinesterase ( AChE ), ACP and ALP , with IC 50 values of 0.11, 0.16 and 0.18 mM, respectively. Trimyristin exerts competitive-noncompetitive inhibition on acetylcholinesterase, uncompetitive inhibition on ACP, and competitive/noncompetitive inhibition on ALP. Trimyristin restores the downregulated acetylcholinesterase concentration in the cerebral cortex of rats exposed to sodium arsenite. Trimyristin can be used in studies related to fascioliasis and neurotoxicity.
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