Other grades of this product :
| GNE 7915 Basic information |
| Product Name: | GNE 7915 | | Synonyms: | GNE 7915;[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone;GNE-7915, >=98%;(4-((4-(Ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morphol;(4-((4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone;CS-1279;GNE7915; GNE 7915;Methanone, [4-[[4-(ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinyl- | | CAS: | 1351761-44-8 | | MF: | C19H21F4N5O3 | | MW: | 443.4 | | EINECS: | | Product Categories: | Inhibitors;api | | Mol File: | 1351761-44-8.mol |
| GNE 7915 Chemical Properties |
| Melting point | 143 - 144°C | | Boiling point | 629.9±65.0 °C(Predicted) | | density | 1.404±0.06 g/cm3(Predicted) | | solubility | Chloroform (Slightly), DMSO (Slightly) | | form | solid | | pka | 2.80±0.10(Predicted) | | CAS DataBase Reference | 1351761-44-8 |
| GNE 7915 Usage And Synthesis |
| Uses | Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. GNE-7915 is a selective, brain-penetrable LRRK2 inhibitor (Kis = 2 and 18.7 nM in biochemical and cell-based assays, respectively). It inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation with an IC50 value of 20 nM in vivo.[Cayman Chemical] | | Uses | GNE-7915 is a Blood-Brain Barrier (BBB) penetrable small molecule inhibitor of Leucine-Rich Repeat Kinase 2 (LRRK2). |
| GNE 7915 Preparation Products And Raw materials |
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