Other grades of this product :
| AG 490 Chemical Properties |
| Melting point | 215 | | Boiling point | 615.2±55.0 °C(Predicted) | | density | 1.337±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | ethanol: 5 mg/mL | | form | solid | | pka | 8.82±0.35(Predicted) | | color | yellow | | CAS DataBase Reference | 134036-52-5(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38-50-25 | | Safety Statements | 26-36-61-45 | | WGK Germany | 1 | | Hazard Note | Irritant/Keep Cold under -20C | | HS Code | 2926907090 |
| AG 490 Usage And Synthesis |
| Chemical Properties | Pale Yellow-Green Crystal | | Uses | A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo. | | Uses | Tyrphostin B42 is used in acute lymphoblastic leukemia studies the compound has been reported to inhibit JAK2 from B cell precursors. |
| AG 490 Preparation Products And Raw materials |
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