Thiolutin

Overview

Thiolutin (Acetopyrrothin) is a sulfur-containing antibiotic , which is a potent inhibitor of bacterial and yeast RNA polymerases. Thiolutin can be produced by Streptomyces . Thiolutin inhibits AMSH ( IC 50 = 4 μM) and Rpn11 ( IC 50 = 0.53 μM). Thiolutin is a dual inhibitor of BRCC36 and the NLRP3 inflammasome , exhibiting anti-inflammatory effects. Thiolutin effectively suppresses the interaction between BRCC36 and HMGCR , leading to the inhibition of HCC growth. Thiolutin attenuates pyroptosis and NLRP3 inflammasome activation. Thiolutin markedly alleviates renal injury and inflammatory process in IgAN. Thiolutin is an anti-angiogenic compound which can ease Doxorubicin-induced cardiotoxicity (DOXIC) [1][2][3][4][5] .

Application

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Product Information

• Catalog No.: HY-N6712
• CAS No.: 87-11-6
• Molecular Formula: C8H8N2O2S2
• Molecular Weight: 228.29
• Purity: 99.27%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source