1,3,5-Tricaffeoylquinic acid acts as an angiogenesis inhibitor and apoptosis inducer, and exhibits anti- HIV activity. 1,3,5-Tricaffeoylquinic acid inhibits the phosphorylation of VEGFR2 , ERK , PI3K , Akt and mTOR in the angiogenesis signaling pathway. 1,3,5-Tricaffeoylquinic acid regulates apoptosis-related proteins, upregulates the levels of activated caspase-8 , Bax , activated PARP and caspase-3/9 , while downregulates the level of Bcl-2 . 1,3,5-Tricaffeoylquinic acid inhibits tube formation and shows cytotoxicity against ovarian cancer cells. 1,3,5-Tricaffeoylquinic acid can be used in studies related to ovarian cancer .
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