Schisantherin D is a lignan. Schisantherin D can be isolated from Kadsura interior . Schisantherin D downregulates the expression of ETBR and inhibits the secretion of ECM and ET-1 . Schisantherin D alleviates EtOH + ET-1-induced hepatocyte cytotoxicity. Schisantherin D potently inhibits HIV replication in cells.
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