Pentadecane is an orally active natural plant volatile alkane with anti-inflammatory, analgesic, antipyretic and anti- leishmanial activities. Pentadecane presents IC 50 values of 65.3 μM, 60.5 μM and 194.8 μM against Leishmania infantum promastigotes , amastigotes and intracellular amastigotes, respectively. Pentadecane downregulates the mRNA expression of TNF-α and IL-12 and inhibits the release of inflammatory mediators. Pentadecane arrests the cell cycle of Leishmania infantum and induces apoptosis . Pentadecane can be applied to the research of inflammation and leishmaniasis.
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