Other grades of this product :
| Product Name: | ML234 | | Synonyms: | ML234;ML324;ML243;N-[3-(Dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)benzamide;NCGC00183808-01;ML324(CID-44143209);CS-2198;ML-324;ML324;ML 324 | | CAS: | 1222800-79-4 | | MF: | C21H23N3O2 | | MW: | 349.43 | | EINECS: | | Product Categories: | Inhibitors | | Mol File: | 1222800-79-4.mol |
| ML234 Chemical Properties |
| Melting point | >187oC (dec.) | | Boiling point | 590.1±50.0 °C(Predicted) | | density | 1.188±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,2-8°C | | solubility | DMSO: soluble10mg/mL, clear | | form | powder | | pka | 4.71±0.40(Predicted) | | color | white to light brown | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 |
| ML234 Usage And Synthesis |
| Description | ML324 (1222800-79-4) inhibits JMJD2 histone demethylases. Represses the expression of viral (HCMV and HSV-1) immediate early genes (IC50 ~ 10 μM) and abrogates infection. ML-324 represses the reactivation of HSV from the latent state in sensory neurons.1 | | Uses | ML324 is a JMJD2 demethylase inhibitor. It blocks the initiation of viral lytic infection and HSV-1 reactivation in the sensory ganglia of latently infected mice. | | References | 1) Liang?et al. (2013),?Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency; Sci. Transl. Med.,?5?167ra5 |
| ML234 Preparation Products And Raw materials |
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