Other grades of this product :
| (-)-MK-801 MALEATE Basic information |
| Product Name: | (-)-MK-801 MALEATE | | Synonyms: | (-)-MK-801 MALEATE;(-)-MK 801;(5R)-10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine (Z)-2-butenedioate;(5S,10R)-(-)-5-METHYL-10,11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5,10-IMINE MALEATE;(-)-MK801MALEATE;5H-Dibenzo[a,d]cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (5R,10S)-, (2Z)-2-butenedioate (1:1);MK 801;MK801;C13737;5H-Dibenzo[a,d]cyclohepten-5,10-imine,10,11-dihydro-5-methyl-,(5R,10S) | | CAS: | 121917-57-5 | | MF: | C20H19NO4 | | MW: | 337.37 | | EINECS: | | Product Categories: | Inhibitors | | Mol File: | 121917-57-5.mol |
| (-)-MK-801 MALEATE Chemical Properties |
| solubility | DMSO: >20 mg/mL | | form | solid | | color | white |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | HP1093575 |
| (-)-MK-801 MALEATE Usage And Synthesis |
| Biological Activity | (+)-mk 801 maleate is a potent antagonist of nmda with ki value of 30.5nm [1].mk 801 is a potent anticonvulsant exhibits both anxiolytic and sympathomimetic properties. it is found to be a noncompetitive antagonist of nmda. mk 801 can penetrate into the central nervous system. in the in vitro assay, mk 801 binds to rat cerebral cortical membrane with high affinity in a saturable manner. this binding is reversible even when the concentration of mk 801 is up to 100μm. it is also found that the binding shows a regional specificity. most of these binding sites are located in the hippocampus. in rat cortical-slice preparations, mk 801 causes a potent blockade of depolarizing responses to nmda with a high selectivity. this effect is persistent. the blockade can also cause a suppression of the epileptiform activity induced by tetrodotoxin or other neurotoxin [1]. | | references | [1] wong eh, kemp ja, priestley t, knight ar, woodruff gn, iversen ll . the anticonvulsant mk-801 is a potent n-methyl-d-aspartate antagonist. proc natl acad sci u s a. 1986 sep;83(18):7104-8. |
| (-)-MK-801 MALEATE Preparation Products And Raw materials |
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