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| FMoc-α-Me-Lys(Boc)-OH Basic information |
| Product Name: | FMoc-α-Me-Lys(Boc)-OH | | Synonyms: | (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-((tert-butoxycarbonyl)amino)-2-methylhexanoic acid;N6-[(1,1-Dimethylethoxy)carbonyl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-methyl-L-lysine;(S)-N-ALPHA-FMOC-N-EPSILON-BOC-ALPHA-METHYLLYSINE;(S)-NΑ-FMOC-NΩ-BOC-Α-METHYLLYSINE;(S)-Na-Fmoc-NW-Boc-α-Methyllysine;Fmoc-alpha-Me-L-Lys(Boc)-OH;(2S)-6-{[(tert-butoxy)carbonyl]amino}-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylhexanoic acid;(9H-Fluoren-9-yl)MethOxy]Carbonyl Alpha-Methyl-Lys(Boc)-OH | | CAS: | 1202003-49-3 | | MF: | C27H34N2O6 | | MW: | 482.57 | | EINECS: | | Product Categories: | α-Methyl Amino Acids | | Mol File: | 1202003-49-3.mol |
| FMoc-α-Me-Lys(Boc)-OH Chemical Properties |
| Boiling point | 687.9±55.0 °C(Predicted) | | density | 1.196±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 3.92±0.41(Predicted) | | form | powder | | color | white |
| FMoc-α-Me-Lys(Boc)-OH Usage And Synthesis |
| Chemical Properties | White to off-white powder. | | Uses | (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-((tert-butoxycarbonyl)amino)-2-methylhexanoic acid is a reagent in the preparation/biological evaluation of a vapreotide analogs containing (S)?-?α-?methyl-?lysine. | | Uses | (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-((tert-butoxycarbonyl)amino)-2-methylhexanoic acid is a reagent in the preparation/biological evaluation of a vapreotide analogs containing (S)-α-methyl-lysine. | | Synthesis | Benzyl (2R,3S)-(?)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate (4) was successively alkylated with methyl iodide and 1,4-diiodobutane using a base. In each alkylation step anti-alkylated product formed exclusively. The iodo group was displaced with azide, which served as a precursor for the side-chain amino function. Catalytic hydrogenation with concomitant cleavage of the chiral auxiliary afforded (L)-α-Me-Lys-OH (9) in a total of four steps in good yield. (L)-Fmoc-α-Me-Lys(Boc)-OH (16) was obtained from 9 via regioselective benzyloxycarbonylation. Alternately, (L)-Fmoc-α-Me-Lys(Boc)-OH (16) was obtained via Staudinger reduction of azide (8) in a total of six steps in good yield. |
| FMoc-α-Me-Lys(Boc)-OH Preparation Products And Raw materials |
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