6-O-Methacrylate, a trilobolide, is isolated from the leaves of Wedelia trilobata . 6-O-Methacrylate displays marked antimalarial activity, with IC 50 of 8.9 μg/mL against P. falciparum parasite . 6-O-Methacrylate also has anti-tobacco mosaic virus ( TMV ) activity.
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