Vinaxanthone (SM-345431) is a potent and selective semaphorin3A , phospholipase C (PLC) and FabI inhibitor, with IC 50 s of 0.1-0.2 μM and 0.9 mM for semaphorin3A and FabI . Vinaxanthone inhibits the substrate (t-o-NAC thioester) and the cofactor (NADPH) with K i s of 3.1 μM and 1.0 μM, respectively. Vinaxanthone can be used to handle infections caused by multidrug-resistant pathogens.
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