S7 is an inhibitory polypeptide targeting IL-6R , which specifically binds to IL-6R and its A chain ( gp80/IL-6RA ) to block its signal transduction. S7 inhibits IL-6-mediated anti-apoptosis ( apoptosis ), angiogenesis and the expression of VEGF-A , blocks related survival signaling pathways, and enhances the sensitivity of cancer cells to chemotherapeutic drugs. S7 can be applied to the research of related diseases such as cervical cancer , multiple myeloma, Kaposi's sarcoma, prostate cancer and basal cell carcinoma.
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