Peptide R analogue 10 (compound 10) is an analog of the CXCR4 antagonist peptide Peptide R ( HY-P4111 ) with stronger antagonistic potency, specificity and plasma stability. Peptide R analogue 10 can inhibit CXCL12 -mediated cell migration, ERK phosphorylation and CXCR4 internalization. Peptide R analogue 10 can be used in the study of CXCR4 overexpressing leukemia and colon cancer .
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