Temporin-Sha is an antibacterial peptide with extensive biological activity. Temporin-Sha exhibits broad-spectrum antibacterial activity (e.g., against L. ivanovii , MIC = 6.25 μM), and is effective against Gram-negative bacteria (such as Escherichia coli , MIC = 10 μM), including drug-resistant strains (such as Methicillin ( HY-121544 )-resistant Staphylococcus aureus ). Temporin-Sha also has inhibitory effects on Candida albicans ( MIC = 25 μM), Saccharomyces cerevisiae ( MIC = 12 μM), the pre-flagellated and non-flagellated forms of Leishmania infantum ( IC 50 = 5-20 μM), and Trypanosoma cruzi ( IC 50 = 17 μM). Temporin-Sha exhibits antiviral activity against HSV-1 and has anti-cancer effects (cytotoxicity against breast cancer cells MCF-7 and lung cancer cells H460, etc.).
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