Ac-RYYRWK-NH2 is a potent and selective partial agonist for the nociceptin receptor (NOP) , [ 3 H]Ac-RYYRWK-NH2 binds to rat cortical membranes ORL1 with a K d of 0.071 nM, but has no affinity for μ-, κ- or δ-opioid receptors.
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