AT-13148

CAS No.：1056901-62-2

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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AT-13148 Basic information

Product Name:	AT-13148
Synonyms:	AT-13148;(+)-(S)-2-Amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)phenyl]ethanol;AT13148 HCl;AT13148 hydrochloride;AT-13148; AT 13148; AT13148; AT13148 HYDROCHLORIDE; AT13148 HCL;AT-13148;AT 13148;CS-1252;(alphaS)-alpha-(Aminomethyl)-alpha-(4-chlorophenyl)-4-(1H-pyrazol-4-yl)benzenemethanol
CAS:	1056901-62-2
MF:	C17H16ClN3O
MW:	313.78
EINECS:
Product Categories:	Inhibitors
Mol File:	1056901-62-2.mol

AT-13148 Chemical Properties

Boiling point	595.9±50.0 °C(Predicted)
density	1.328±0.06 g/cm3(Predicted)
solubility	Soluble in DMSO
pka	10.92±0.50(Predicted)

Safety Information

MSDS Information

AT-13148 Usage And Synthesis

Uses	AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor.
Biological Activity	at13148 is a novel, oral and atp-competitive inhibitor of multi-agc kinase with ic50 values of 38nm, 8nm, 3nm, 63nm and 4nm for akt, p70s6 kinase, pka, sgk and rho kinase, respectively [1].
in vitro	studies, at13148 has been reported to inhibit activity of agc kinases which including akt, p70s6 kinase, pka, sgk and rho kinase with the ic50 values of 38nm, 8nm, 3nm, 63nm and 4nm, respectively. in addition, at13148 has been revealed to inhibit proliferation with gi50 values of 1.54μm, 1.59μm, 1.82μm, 2.65μm and 3.77μm in mes-sa, bt474, hct-116, a549 and sk-ov-3 cell lines, respectively.
in vivo	studies, at13148 has shown the antitumor activity in multiple human tumor xenograft models including pten-deficient mes-sa human uterine sarcoma, her2-positive, pik3ca-mutant bt474 human breast cancer xenografts [1].
references	[1] yap ta1, walton mi, grimshaw km, te poele rh, eve pd, valenti mr, de haven brandon ak, martins v, zetterlund a, heaton sp, heinzmann k, jones ps, feltell re, reule m, woodhead sj, davies tg, lyons jf, raynaud fi, eccles sa, workman p, thompson nt, garrett md. at13148 is a novel, oral multi-agc kinase inhibitor with potent pharmacodynamic and antitumor activity. clin cancer res. 2012 jul 15;18(14):3912-23.

AT-13148 Preparation Products And Raw materials

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