Tat-NR2BAA is the control peptide of Tat-NR2B9c ( HY-P0117 ), inactive. The sequence of Tat-NR2BAA is similar to Tat-NR2B9c , but it has a double-point mutation in the COOH terminal tSXV motif, making it incapable of binding PSD-95. Tat-NR2B9c is a membrane-permeant peptide and disrupts PSD-95/NMDAR binding, correlate with uncoupling NR2B- and/or NR2A-type NMDARs from PSD-95.
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