L-Histidine hydrochloride

L-Histidine hydrochloride
  • CAS No.:1007-42-7

Important Notice

  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
  2. This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
  3. The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.
Other grades of this product :
L-Histidine hydrochloride Basic information
Product Name:L-Histidine hydrochloride
Synonyms:H-His-OH.xHCl;L-HISTIDINE DIHYDROCHLORIDE;Crystalline2HCl;L-Histidine hydrochloride;L-Histidine hydrochloride solution;histidine hydrochloride;China Best L-Histidine hydrochloride CAS NO.1007-42-7;L-Histidine hydrochloride CAS NO.1007-42-7
CAS:1007-42-7
MF:C6H10ClN3O2
MW:191.62
EINECS:213-754-2
Product Categories:
Mol File:1007-42-7.mol
L-Histidine hydrochloride Chemical Properties
Melting point 240-245 °C (dec.)
alpha [α]D20 +7.0~+10.0°(c=2,HCl)
storage temp. Inert atmosphere,Room Temperature
CAS DataBase Reference1007-42-7(CAS DataBase Reference)
Safety Information
Safety Statements 22-24/25
RIDADR UN 1789 8/PG 3
WGK Germany 3
F 3-10
MSDS Information
ProviderLanguage
SigmaAldrich English
L-Histidine hydrochloride Usage And Synthesis
Purification MethodsThe dihydrochloride crystallises from water or aqueous EtOH and is washed with acetone, then diethyl ether. Alternatively convert it to the histidine di-(3,4-dichlorobenzenesulfonate) salt by dissolving 3,4-dichlorobenzenesulfonic acid (1.5g/10mL) in the aqueous histidine solution with warming, and then the solution is cooled in ice. The resulting crystals (m 280o dec) can be recrystallised from 5% aqueous 3,4-dichlorobenzenesulfonic acid, then dried over CaCl2 under vacuum, and washed with diethyl ether to remove Purification of Biochemicals — Amino Acids and Peptides excess reagent. The dihydrochloride can be regenerated by passing the solution through a Dowex-1 (Cl-form) ion-exchange column. The solid is obtained by evaporation of the solution on a steam bath or better in a vacuum. [Greenstein & Winitz, The Amino Acids Vol 3 p 1976 1961, Beilstein 25/16 V 366.]
L-Histidine hydrochloride Preparation Products And Raw materials
Raw materialsHEMOGLOBIN
Preparation ProductsN-Boc-L-Histidine

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