Curcumin

CAS No.：458-37-7

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Other grades of this product :

Melting point	183 °C
Boiling point	418.73°C (rough estimate)
density	0.93
vapor density	13 (vs air)
refractive index	1.4155-1.4175
Fp	208.9±23.6 °C
storage temp.	2-8°C
solubility	ethanol: 10 mg/mL
pka	8.09(at 25℃)
form	powder
Colour Index	75300
color	orange
Odor	Odorless
PH Range	Yellow (7.8) to red-brown (9.2)
Water Solubility	Slightly soluble (hot)
λmax	430nm
Merck	14,2673
Concentration	1 mCi/ml
BRN	2306965
Solvent	Ethanol
Specific Activity	5-15 Ci/mmol
Stability:	Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
Major Application	Cosmetics, drug-eluting stents, inhibition of formation of skin-wrinkles, treating alzheimer’s disease, skin diseases, coronary restenosis, diabetes, obesity, leukemia, neurofibromas, cancer, antimicrobial, antiviral, antiinflammatory, antiprostate cancer
InChIKey	VFLDPWHFBUODDF-FCXRPNKRSA-N
CAS DataBase Reference	458-37-7(CAS DataBase Reference)
EPA Substance Registry System	Curcumin (458-37-7)

Anaturalphenoliccompound.Potentanti-tumoragenthavinganti-inflammatoryandantioxidantproperties.Inducesapoptosisincancercellsandinhibitsphorbolester-inducedproteinkinaseC(PKC)activity.Reportedtoinhibitproductionofinflammatorycytokinesbyperipheralbloodmonocytesandalveolarmacrophages.PotentinhibitorofEGFRtyrosinekinaseandIBkinase.ChemicalbookInhibitsinduciblenitricoxidesynthase(iNOS),cycloxygenaseandlipoxygenase.Easilypenetratesintothecytoplasmofcells,accumulatinginmembranousstructuressuchasplasmamembrane,endoplasmicreticulumandnuclearenvelope.CurcuminiscurrentlybeingexaminedasapossibletherapeuticforthetreatmentofAlzheimersdisease(Chem.andEng.News90(31),44(2012)).

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