Dioctyl phthalate -d 4 (DNOP-d 4 ) is the d 4 -labeled Dioctyl phthalate ( HY-W013755 ). Dioctyl phthalate (DNOP) is a plasticizer. Dioctyl phthalate increases the activities of alanine aminotransferase ( ALT ) and alkaline phosphatase ( ALP ) in the liver, as well as the levels of creatinine and urea in the kidney. Exposure to Dioctyl phthalate disrupts the homeostasis of the intestinal microbial community, increases the abundance of pathogenic bacteria, and reduces the abundance of beneficial bacteria such as Lactobacillus . Dioctyl phthalate induces significant and dose-dependent inflammatory responses in the liver, spleen and kidney of mice.
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