(E)-5-(2-Bromovinyl)pyrimidine-2,4(1H,3H)-dione

Overview

(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil ( HY-90006 ) in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, increasing survival time.

Application

Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Infection | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-W014109
• CAS No.: 69304-49-0
• Molecular Formula: C6H5BrN2O2
• Molecular Weight: 217.02
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source