L-Asparagine-amide- 15 N monohydrate

Overview

L-Asparagine-amide- 15 N monohydrate is the 15 N-labeled L-Asparagine monohydrate ( HY-W017443 ). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase . L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis . L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase ( AASNS ) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.

Application

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Product Information

• Catalog No.: HY-W017443S1
• CAS No.: 204451-47-8
• Molecular Formula: C4H10N15NO4
• Molecular Weight: 151.13
• Purity: 99.80%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Availability: In-stock

Source

Original product source