Chromomycin A3 (Standard)

Overview

Chromomycin A3 (Standard) is the analytical standard of Chromomycin A3 ( HY-W040129 ). This product is intended for research and analytical applications. Chromomycin A3 is an inhibitor that selectively binds to GC-rich DNA sequences . Chromomycin A3 targets the DNA minor groove after forming a dimer with Mg 2+ . Chromomycin A3 inhibits DNA replication and transcription, blocks the binding of Sp1 transcription factor to target gene promoters, downregulates the expression of anti-apoptotic proteins such as FLIP, Mcl-1 , and XIAP , and induces S-phase cycle arrest and caspase-dependent apoptosis in tumor cells. Chromomycin A3 can antagonize oxidative stress induced by glutathione depletion and neuronal apoptosis induced by Camptothecin ( HY-15660 ). Chromomycin A3 can be used in basic research on malignant tumors such as cholangiocarcinoma, and is a potential chemosensitizer and GC-rich region probe.

Application

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Product Information

• Catalog No.: HY-W040129R
• CAS No.: 7059-24-7
• Molecular Formula: C57H82O26
• Molecular Weight: 1183.25
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source