Geranial is an aromatic compound. It can be isolated from the fruits of Litsea cubeba Lour and the rhizomes of ginger ( Zingiber officinale ). Geranial inhibits LPS-induced phosphorylation of ERK1/2 , JNK1/3 and IκB in macrophages. It suppresses the secretion of IL-1β , TNF-α and IL-6 , as well as the expression of pro-IL-1β , iNOS and COX-2 . Geranial increases ROS . It can be used in the research of inflammatory diseases.
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