Diethyl ethoxymethylenemalonate

Melting point	-33°C
Boiling point	279-283 °C(lit.)
density	1.080 g/mL at 20 °C(lit.)
vapor pressure	<0.1 hPa
refractive index	n20/D1.463
Fp	311 °F
storage temp.	Store below +30°C.
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
form	Liquid
color	Clear colorless to light yellow
Water Solubility	insoluble
BRN	880058
InChIKey	LTMHNWPUDSTBKD-UHFFFAOYSA-N
LogP	1.5-2.1 at pH7
CAS DataBase Reference	87-13-8(CAS DataBase Reference)
NIST Chemistry Reference	Propanedioic acid, (ethoxymethylene)-, diethyl ester(87-13-8)
EPA Substance Registry System	Propanedioic acid, (ethoxymethylene)-, diethyl ester (87-13-8)

Diethyl ethoxymethylenemalonate is used for synthesis of pyrido[3,2-e]pyrimido[1,2-c]pyrimidines. Initially, it was used to monitor lysine decarboxylase activity. It is useful in the determination of amino acids by precolumn derivatization by using reversed-phase high-performance liquid chromatography (HPLC). It plays an important role in the Gould-Jacobs reaction to prepare quinolines. For example, anile reacts with this reagent to give 4-hydroxyquinoline. It acts as an intermediate in the production of flumequine, which is a fluoroquinolone antibiotic.