Thalidomide-1-Me,4-OH

Overview

Thalidomide -1-Me,4-OH is a Thalidomide ( HY-14658 ) analogue. Thalidomide -1-Me,4-OH contains an extra methyl group on the glutarimide moiety of thalidomide, which is known to abrogate its ability to bind the E3 ligase CRBN. Thalidomide is a ligand for E3 ligase , which ubiquitinylates proteins, thus committing their fate to proteolytic destruction.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Ligands for E3 Ligase

Product Information

• Catalog No.: HY-W441376
• CAS No.: 2244568-06-5
• Molecular Formula: C14H12N2O5
• Molecular Weight: 288.26
• Purity: 98.0%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source