IMipenem and cilastatin sodium is a broad-spectrum Carbapenem Antibiotic combination. Imipenem ( HY-B1369A ) is a Carbapenem antibiotic . IMipenem demonstrates excellent activity against gram-positive and gram-negative aerobic and anaerobic organisms. Cilastatin ( HY-A0166 ) is a renal Dehydropeptidase inhibitor that inhibits the metabolism of Imipenem by renal brush-border enzymes , thus increasing imipenem concentrations in urine.
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