Thalidomide -NH-(CH2)2-NH-Boc is a Boc-modified Thalidomide ( HY-14658 ) that acts as a Cereblon ligand to recruit CRBN protein. The Boc protecting group at the end of Thalidomide -NH-(CH2)2-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide -NH-(CH2)2-NH-Boc is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
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