2-(2,6-Dioxopiperidin-3-yl)phthalimidine NMe is an E3 ligase ligand of SIAIS630121-NC ( HY-159016 ). 2-(2,6-Dioxopiperidin-3-yl)phthalimidine NMe contains an extra methyl group on the glutarimide moiety of thalidomide, which is known to abrogate its ability to bind the E3 ligase CRBN. SIAIS630121-NC is a negative control for NAMPT degrader SIAIS630121.
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