(S)-ML188 is a SARS-CoV 3-chymotrypsin-like protease ( 3CLpro ) inhibitor ( IC 50 : 1.5 μM). (S)-ML188 has antiviral activity with an EC 50 value of 12.9 μM against SARS-CoV . (S)-ML188 inhibits the activity of 3CLpro via non-covalent binding and can be used in the study of SARS-CoV .
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