Dihydroflavokawin B is a selective COX-1 inhibitor with an IC 50 of 1.22 μM. Dihydroflavokawin B weakly inhibits COX-2 and 5-LOX . Dihydroflavokawin B inhibits promastigote forms of Leishmania panamensis and Leishmania braziliensis . Dihydroflavokawin B inhibits rabbit platelet aggregation induced by Arachidonic acid, platelet activating factor, and adenosine diphosphate. Dihydroflavokawin B exhibits in vitro anti-inflammatory activity. Dihydroflavokawin B can be used for the research of leishmaniasis.
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