Harman-d 3

Overview

Harman-d 3 is deuterium labeled Harmane. Harmane is a benzodiazepine receptor inhibitor ( IC 50 =7 μM), with IC 50 values for mACh , Opioid Receptor , MAO-A/B , and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin , with IC 50 values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor ( IC 50 =30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF).

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Others | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Isotope-Labeled Compounds

Product Information

• Catalog No.: HY-W700834
• CAS No.: 1216708-84-7
• Molecular Formula: C12H7D3N2
• Molecular Weight: 185.24
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source