(R)-Colchicine

Overview

(R)-Colchicine is the R-isomer of Colchicine ( HY-16569 ). Colchicine , an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC 50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs) . Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research.

Application

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Product Information

• Catalog No.: HY-W741136
• CAS No.: 75520-89-7
• Molecular Formula: C22H25NO6
• Molecular Weight: 399.44
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source