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| 4-Nonylphenylboronic acid Basic information |
| Product Name: | 4-Nonylphenylboronic acid | | Synonyms: | 4-N-NONYLBENZENEBORONIC ACID, 98+%;4-Nonylphenylboronic acid;1-Borono-4-(non-1-yl)benzene;4-(Non-1-yl)benzeneboronic acid;4-N-NONYLPHENYLBORONIC ACID;4-N-NONYLBENZENEBORONIC ACID;AKOS BRN-0129;Boronic acid, B-(4-nonylphenyl)- | | CAS: | 256383-45-6 | | MF: | C15H25BO2 | | MW: | 248.17 | | EINECS: | 000-000-0 | | Product Categories: | | Mol File: | 256383-45-6.mol |
| 4-Nonylphenylboronic acid Chemical Properties |
| Melting point | 82-85°C | | Boiling point | 385.3±35.0 °C(Predicted) | | density | 0.97±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO (up to 30 mg/ml) | | form | solid | | pka | 8.72±0.16(Predicted) | | color | White | | Water Solubility | Insoluble in water. | | BRN | 8215118 | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. | | CAS DataBase Reference | 256383-45-6(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | Hazard Note | Irritant | | HS Code | 2931900090 |
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ALFA
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| 4-Nonylphenylboronic acid Usage And Synthesis |
| Description | Nonylbenzeneboronic acid (CAS 256383-45-6) is a potent and selective inhibitor of fatty acid amide hydrolase (FAAH, the enzyme which hydrolyzes and deactivates anandamide), IC50=9.1 nM1. Also inhibits monoacylglycerol lipase (MAGL, the enzyme which hydrolyzes 2-arachidonoyl-glycerol), IC50=7.9 μM.1 | | Uses | 4-n-Nonylbenzeneboronic acid is a potent inhibitor of fatty acid amide hydrolase. It is also able to inhibit monoacylglycerol lipase (MAGL), which hydrolyzes 2-arachidonoyl glycerol (2-AG). | | in vitro | 4-(n-nonyl) benzeneboronic acid was synthezed as a potent inhibitor of faah, with an ic50 of 9.1 nm. 4-(n-nonyl) benzeneboronic acid was also found to be able to inhibit magl, which could hydrolyze 2-arachidonoyl glycerol, but at around 1000-fold higher concentration. moreover, it was found that as the most potent para-substituted compound, 4-(n-nonyl) benzeneboronic acid showed rather high pka of 9.1. in addition, the molecular docking was utilized to gain insight on the faah binding mode of 4-(n-nonyl) benzeneboronic acid and a putative binding mode was observed [1]. | | IC 50 | 9.1 nm | | References | 1) Minkkila?et al.?(2008),?Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase; J. Med. Chem.,?51?7057 |
| 4-Nonylphenylboronic acid Preparation Products And Raw materials |
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