SMART1

Overview

SMART1 is a highly specific and CRBN-dependent PROTAC that can effectively degrade Smurf1 . SMART1 can block the PDK1-Akt signaling pathway in KRAS mutant colorectal cancer . SMART1 can inhibit tumor growth in KRAS mutant colorectal cancer (CRC) xenograft models. (Pink: Smurf1 ligand ( HY-169049 ); Blue: Cereblon ligand ( HY-14658 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > PDK-1 | Products > Signaling Pathways > Akt

Product Information

• Catalog No.: HY-W998345
• CAS No.: 3070172-53-8
• Molecular Formula: C40H35N9O7
• Molecular Weight: 753.76
• Purity: 99.87%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source