2,5-Hexanedione-d 10 (2,5-HD-d 10 ) is the deuterium labeled 2,5-Hexanedione. Hexane-2,5-dione (2,5-HD) is an orally active, CNS-penetrant cytotoxic agent . Hexane-2,5-dione reduces BCL-2 and β-catenin / TCF transcriptional activity, increases BAX and active caspase-3 expression, and promotes apoptosis . Hexane-2,5-dione causes an accumulation of neurofilaments within axons in rats. Hexane-2,5-dione can be used for the research of neurodegenerative diseases.
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