WZB 117

Overview

WZB 117 is a GLUT inhibitor (Ki(app) = 0.2, 10 and 10 μM for GLUT4, GLUT1 and GLUT3, respectively) that inhibits passive glucose transport in human erythrocytes and cancer cell lines. It decreases extracellular lactate and intracellular ATP levels. WZB 117 was shown to attenuate erythrocyte 3-O-metylglucose (3MG) uptake in vitro (Ki = 6 μM) and inhibits tumor growth in a nude mouse model.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Endocrinology and Metabolic Disease | GLUT(Glucose transporter)

Product Information

• Catalog No.: B0084-170394
• CAS No.: 1223397-11-2
• Molecular Formula: C20H13FO6
• Molecular Weight: 368.31
• Purity: ≥98% by HPLC

Source

Original product source